Abstract: Objective ：To explore the clinical application of digital smile design (DSD) technology in the esthetics restoration of upper anterior teeth. Methods From January 2016 to December 2017, fifty patients with esthetic problems in their upper anterior teeth were included and divided into two groups randomly: experimental group (n=25) and control group (n=25). Experimental group were treated under DSD design guidance, while control group were treated with the traditional design method. The adjustment time of each temporary/final restoration and Howard B. Kay’s Classification of Altered Dental Esthetics changes in both groups were recorded. Besides, the satisfaction to the final restoration was evaluated by the patients. Results The adjustment time of the experimental group was much shorter than that in the control group (P<0.05). And the satisfaction rate of the patients to final restoration was higher in experimental group than in control group. Conclusions DSD plays an important role in the esthetic restoration of the upper anterior teeth. It helps medical staff to understand patients’ dental dynamic aesthetics information more comprehensively. It also guides the whole process of the treatment and improves the satisfaction of the patients.