›› 2019, Vol. 10 ›› Issue (4): 222-226.

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Research Progress of LuxS/AI-2 quorum sensing system and oral pathogens

1,Changbo-Bo WEI   

  • Received:2019-04-09 Revised:2019-11-10 Online:2019-12-25 Published:2020-01-06
  • Contact: Changbo-Bo WEI E-mail:weichb@mail2.sysu.edu.cn

Abstract: There are many kinds of bacteria in the oral microenvironment, and the coexistence of bacteria is realized by the form of biofilm between bacteria and bacteria. The LuxS/AI-2 quorum sensing system is present in a variety of Gram-positive and negative bacteria. By integrating specific quorum sensing signals, bacteria can distinguish between autologous and non-autologous, thereby initiating the expression of bacterial-related genes, further precisely regulating biological behaviors to adapt environment, such as bioluminescence, release of virulence factors, and biofilm formation. In this review, we focus on the generation of AI-2, regulation of quorum sensing system and related research in oral pathogens.

Key words: LuxS, AI-2, quorum sensing, oral pathogens