延缓间充质干细胞衰老的研究进展

doi:10.3969/j.issn.1674-8603.2020.02.014

Abstract

Abstract: Mesenchymal stem cells (MSCs) have been one of the most important cell sources in regenerative medicine on account of some outstanding advantages, e.g. low immunogenicity, strong anti - inflammatory and immune regulation. Nevertheless, the clinical development and application of MSCs are exceedingly restricted due to the characteristic of easy-aging in vitro culture. The issue on how to alleviate the senescence of MSCs is drawing much attention of both domestic and overseas researchers. This review summarizes MSCs aging signaling pathways and the process of related researches, to provide new insights to effective clinical applications of MSCs.

Key words: mesenchymal stem cells, senescence, alleviate, oxidative stress

References 61

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Research advances in alleviating the senescence of mesenchymal stem cells

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