›› 2020, Vol. 11 ›› Issue (3): 191-196.
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Received:2020-04-20
Revised:2020-09-13
Online:2020-09-25
Published:2020-09-30
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| [1] | Beisiegel U, Weber W, Ihrke G, et al.The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein[J].Nature, 1989, 341(6238):162-164 |
| [2] | Solanki I, Parihar P, Parihar MS.Neurodegenerative diseases: From available treatments to prospective herbal therapy[J].Neurochem Int, 2016, 95:100-108 |
| [3] | Brinkman AB, Ettema TJG, de Vos WM, et al.The Lrp family of transcriptional regulators[J].Mol Microbiol, 2003, 48(2):287-294 |
| [4] | Nykjaer A, Willnow T E.The low-density lipoprotein receptor gene family: a cellular Swiss army knife?[J].Trends in Cell Biology, 2002, 12(6):273-280 |
| [5] | Li Y, Cam J, Bu G.Low-density lipoprotein receptor family: Endocytosis and signal transduction[J].Mol Neurobiol, 2001, 23(1):53-67 |
| [6] | Chang TH, Hsieh FL, Zebisch M, et al.Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan[J].Elife, 2015, 4:e06554- |
| [7] | Shen CY, Xiong WC, Mei L.LRP4 in neuromuscular junction and bone development and diseases[J].Bone, 2015, 80:101-108 |
| [8] | Zhang J, Zhang XF, Zhang L, et al.LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation[J].J Bone Miner Res, 2012, 27(10):2065-2074 |
| [9] | Lara-Castillo N, Johnson ML.LRP receptor family member associated bone disease[J].Rev Endocr Metab Disord, 2015, 16(2):141-148 |
| [10] | 吕赵劼, 王志浩, 卢淑娴, 等.短指(趾)症及指(趾)骨发育的分子调控机制[J].遗传, 2019, 41(12):1073-1083 |
| [11] | Laeremans H, Rensen SS, Ottenheijm HCJ, et al.Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts[J].Cardiovasc Res, 2010, 87(3):514-523 |
| [12] | Riddle RC, Diegel CR, Leslie JM, et al.Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition[J].PLoS One, 2013, 8(5):e63323- |
| [13] | Xiong L, Jung JU, Wu HT, et al.Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption[J].Proc Natl Acad Sci U S A, 2015, 112(11):3487-3492 |
| [14] | Tanahashi H, Tian QB, Hara Y, et al.Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance[J].Sci Rep, 2016, 6:20241- |
| [15] | Zeng X, Tamai K, Doble B, et al.A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation[J].Nature, 2005, 438(7069):873-877 |
| [16] | Holdsworth G, Slocombe P, Doyle C, et al.Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of wnt Co-receptors[J].J Biol Chem, 2012, 287(32):26464-26477 |
| [17] | Gong Y.Osteoporosis-Pseudoglioma Syndrome Collaborative GroupLDL receptor-related protein (LRP5) affects bone accrual and eye development[J].Cell, 2001, 107(4):513-523 |
| [18] | Kato M, Patel MS, Levasseur R, et al.Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor[J].J Cell Biol, 2002, 157(2):303-314 |
| [19] | Mani A, Radhakrishnan J, Wang H, et al.LRP6 mutation in a family with early coronary disease and metabolic risk factors[J].Science, 2007, 315(5816):1278-1282 |
| [20] | Holmen SL, Giambernardi TA, Zylstra CR, et al.Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6[J].J Bone Miner Res, 2004, 19(12):2033-2040 |
| [21] | 邵金辉, 王志浩, 刘聪, 等.LRP4与人类罕见遗传病[J].生命科学, 2018, 30(8):855-861 |
| [22] | Johnson EB, Hammer RE, Herz J.Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice[J].Hum Mol Genet, 2005, 14(22):3523-3538 |
| [23] | Grotewold L, Rüther U.The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death[J].EMBO J, 2002, 21(5):966-975 |
| [24] | Boyden LM, Mao JH, Belsky J, et al.High bone density due to a mutation in LDL-receptor–related protein 5[J].N Engl J Med, 2002, 346(20):1513-1521 |
| [25] | Little RD, Carulli JP, del Mastro RG, et al.A mutation in the LDL receptor-related protein 5 gene results in the autosom al dominant high-bone-mass trait[J].Am J Hum Genet, 2002, 70(1):11-19 |
| [26] | Van Wesenbeeck L, Cleiren E, Gram J, et al.Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density[J].Am J Hum Genet, 2003, 72(3):763-771 |
| [27] | Mao BY, Wu W, Davidson G, et al.Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling[J].Nature, 2002, 417(6889):664-667 |
| [28] | 袁琦, 杨静蕾, 孙梦悦, 等.LRP5基因D111Y1突变导致常染色体显性遗传性型骨硬化症一家系报道[J].中华内分泌代谢杂志, 2020, 36(1):36-42 |
| [29] | Li XD, Ominsky MS, Niu QT, et al.Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength[J].J Bone Miner Res, 2008, 23(6):860-869 |
| [30] | Li XF, Zhang YZ, Kang H, et al.Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling[J].J Biol Chem, 2005, 280(20):19883-19887 |
| [31] | Fijalkowski I, Geets E, Steenackers E, et al.A novel domain-specific mutation in a sclerosteosis patient suggests a role of LRP4 as an anchor for sclerostin in human bone[J].J Bone Miner Res, 2016, 31(4):874-881 |
| [32] | Winkler DG.Osteocyte control of bone formation via sclerostin, a novel BMP antagonist[J].EMBO J, 2003, 22(23):6267-6276 |
| [33] | Leupin O, Piters E, Halleux C, et al.Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function[J].J Biol Chem, 2011, 286(22):19489-19500 |
| [34] | Lodewyckx L, Luyten F, Lories R, et al.Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis[J].Rheumatology, 2012, 51(11):1973-1978 |
| [35] | Shin Y, Huh YH, Kim K, et al.Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction[J].Arthritis Res Ther, 2014, 16(1):R37- |
| [36] | Papathanasiou I, Malizos KN, Tsezou A.Bone morphogenetic protein-2-induced Wntβ-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes[J].Arthritis Res Ther, 2012, 14(2):R82- |
| [37] | Miao CG, Yang YY, He X, et al.Wnt signaling pathway in rheumatoid arthritis,with special emphasis on the different roles in synovial inflammation and bone remodeling[J].Cell Signal, 2013, 25(10):2069-2078 |
| [38] | Kokubu C.Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis[J].Development, 2004, 131(21):5469-5480 |
| [39] | Hettiaracchchi D, Bonnard C, Jayawardana SMA, et al.Cenani-Lenz syndactyly syndrome - a case report of a family with isolated syndactyly[J].BMC Med Genet, 2018, 19(1):125- |
| [40] | Afzal M, Zaman Q, Kornak U, et al.Novel splice mutation in LRP4 causes severe type of Cenani-Lenz syndactyly syndrome with oro-facial and skeletal symptoms[J].Eur J Med Genet, 2017, 60(8):421-425 |
| [41] | Tian J, Shao JH, Liu C, et al.Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged–Notch signaling in fin and limb development[J].Cell Mol Life Sci, 2019, 76(1):163-178 |
| [42] | Li Y, Pawlik B, Elcioglu N, et al.LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome[J].Am J Hum Genet, 2010, 86(5):696-706 |
| [43] | Bueno M, Oliván G, Jiménez A, et al.Sclerosteosis in a Spanish male: First report in a person of Mediterranean origin[J].J Med Genet, 1994, 31(12):976-977 |
| [44] | Ohazama A, Johnson EB, Ota MS, et al.Lrp4 modulates extracellular integration of cell signaling pathways in development[J].PLoS One, 2008, 3(12):e4092- |
| [45] | Ohazama A, Porntaveetus T, Ota MS, et al.Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis[J].Am J Med Genet A, 2010, 152A(12):2974-2983 |
| [46] | Schwarting T, Schenk D, Frink M, et al.Stimulation with bone morphogenetic protein-2 (BMP-2) enhances bone–tendon integration in vitro[J].Connect Tissue Res, 2016, 57(2):99-112 |
| [47] | Padhi D, Allison M, Kivitz AJ, et al.Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal women with low bone mass: A randomized,double-blind,placebo-controlled study[J].J Clin Pharmacol, 2014, 54(2):168-178 |
| [48] | Sinder BP, Eddy MM, Ominsky MS, et al.Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta[J].J Bone Miner Res, 2013, 28(1):73-80 |
| [49] | Kedlaya R, Veera S, Horan DJ, et al.Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome[J].Sci Transl Med, 2013, 5(211):211ra158- |
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