炎症微环境影响牙周膜干细胞成骨分化的信号通路

Abstract

Abstract: Periodontal ligament stem cells (PDLSCs) used in tissue engineering is one of the most promising methods for the treatment of periodontitis with bone loss. However, the effect of PDLSCs in vivo for periodontal tissue regeneration is not ideal, which may be due to the influence of the inflammatory microenvironment of PDLSCs on their fate. Therefore, this review will explore the effect of inflammatory microenvironment on the osteogenic differentiation potential of PDLSCs from the aspect of signal pathway, so as to provide theoretical basis for the prevention and treatment strategy of bone loss in periodontitis.

Key words: periodontitis, periodontal ligament stem cell, inflammatory microenvironment, osteogenesis differentiation, signaling pathways

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Inflammatory microenvironment regulates osteogenic differentiation of periodontal ligament stem cells through various signal pathways

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