Oral Biomedicine ›› 2022, Vol. 13 ›› Issue (3): 180-185.

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Research progress on the relationship between periodontal microorganisms and Alzheimer’s disease

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  • Received:2022-05-13 Revised:2022-07-22 Online:2022-09-25 Published:2022-09-29

Abstract: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly population. However, the etiology and pathogenesis of AD are complicated and remain elucidated. Increasing reports suggest that periodontal microorganisms may play a role in the initiation and progress of AD. Thus, this article will review the association and potential mechanisms between periodontal microorganisms and AD, and explain the significance of management targeting periodontal microorganisms in the treatment of AD.

Key words: Alzheimer’s disease, Periodontal microorganisms, Microbial dysbiosis, Neuroinflammation