mRNA m6A修饰与口腔疾病

Abstract

Abstract: N6-methyladenosine (m6A) is the most prevalent epigenetic modification in eukaryotic mRNAs and involves in multiple biological processes. As a reversible modification, the process m6A counts on three types of proteins: Writers, Erasers and Readers. Recently, emerging evidence elucidates the role of m6A modification in the development of oral tissues and progression of oral diseases. This review summarized the recent papers reporting the research progress of m6A in oral diseases, mainly discussing its regulation of tooth and mandible development, as well as temporomandibular arthritis and mucosal disorders.

Key words: mRNA甲基化, m6A修饰, 口腔疾病

References 46

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The role of m6A mRNA methylation in oral diseases

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