Abstract: Mechanical forces play an important role in tissue development and various physiological and pathological processes, and many molecules, signaling pathways, and ion channels are involved. The mouth is an open environment, the teeth in the mouth will inevitably be stimulated by a variety of mechanical forces, and tooth development is the most important part of the tooth growth process, in this process there are also major factors, and affect the tooth development process to varying degrees. In this paper, the relevant molecules in response to mechanical stimulation in vivo and during tooth development are reviewed, so as to provide ideas for finding a method to promote tooth development and eruption through mechanical stimulation.