术前血红蛋白、白蛋白和球蛋白比值在口腔鳞癌患者预后中的预测价值

Abstract

Abstract: Objective: To explore the predictive value of preoperative hemoglobin, albumin-globulin ratio (HAGR) in the prognosis of patients with oral squamous cell carcinoma (OSCC). Methods: A total of 235 patients with OSCC were enrolled. The correlation between HAGR and clinical parameters was analyzed by chi-square test. Kaplan-Meier analysis was used to evaluate the overall （OS）and disease-free survival rates （DFS）of OSCC patients. Univariate and multivariate regression analysis were used to analyze the independent risk factors affecting the prognosis of OSCC patients. The nomogram was used to observe the survival probability of patients at a specific time point. Results: HAGR value was significantly correlated with gender (P=0.001 3), T stage (P=0.0218), BMI (P=0.024 7) and pathological grade (P=0.0247). Kaplan-Meier analysis showed that HAGR was associated with overall (P＜0. 001) and disease-free survival (P＜0.00 1). Multivariate regression analysis showed that T stage (P=0.003), N stage (P=0.003) and HAGR (P=0.009) were independent predictors of overall survival in patients with oral squamous cell carcinoma. The nomogram showed that HAGR still had a greater weight in predicting survival compared with T stage and N stage. Conclusion: Preoperative HAGR can be used as a prognostic indicator to predict the prognosis of patients with OSCC.

Key words: Oral squamous cell carcinoma, HAGR, Prognosis, nomogram

References 27

[1]	H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA Cancer J Clin, 71 (2021) 209-249.
[2]	A. Chaurasia, S.I. Alam, N. Singh, Oral cancer diagnostics: An overview, Natl J Maxillofac Surg, 12 (2021) 324-332.
[3]	A. Almangush, A.A. Makitie, A. Triantafyllou, R. de Bree, P. Strojan, A. Rinaldo, J.C. Hernandez-Prera, C. Suarez, L.P. Kowalski, A. Ferlito, I. Leivo, Staging and grading of oral squamous cell carcinoma: An update, Oral Oncol, 107 (2020) 104799.
[4]	R. Zhao, Z. Liang, K. Chen, X. Zhu, Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma, J Inflamm Res, 16 (2023) 1995-2006.
[5]	R. Zhao, Z. Liang, K. Chen, X. Zhu, Nomogram Based on Inflammatory Biomarkers and Nutritional Indicators for Predicting Overall Survival in Locoregionally Advanced Nasopharyngeal Carcinoma, J Inflamm Res, 15 (2022) 2971-2981.
[6]	T. Yoshimura, H. Suzuki, H. Takayama, S. Higashi, Y. Hirano, M. Tezuka, T. Ishida, K. Ishihata, M. Amitani, H. Amitani, Y. Nishi, Y. Nakamura, Y. Imamura, E. Nozoe, A. Inui, N. Nakamura, Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma, Front Pharmacol, 13 (2022) 996757.
[7]	X. Bao, F. Liu, J. Lin, Q. Chen, L. Chen, F. Chen, J. Wang, Y. Qiu, B. Shi, L. Pan, L. Lin, B. He, Nutritional assessment and prognosis of oral cancer patients: a large-scale prospective study, BMC Cancer, 20 (2020) 146.
[8]	R. Metgud, S. Patel, Serum and salivary levels of albumin as diagnostic tools for oral pre-malignancy and oral malignancy, Biotech Histochem, 89 (2014) 8-13.
[9]	Y. Yoshino, A. Taguchi, T. Shimizuguchi, Y. Nakajima, M. Takao, T. Kashiyama, A. Furusawa, N. Kino, T. Yasugi, A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy, Int J Gynecol Cancer, 29 (2019) 17-22.
[10]	K. Graham, E. Unger, Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment, Int J Nanomedicine, 13 (2018) 6049-6058.
[11]	J. Li, M.A. Duran, N. Dhanota, W.K. Chatila, S.E. Bettigole, J. Kwon, R.K. Sriram, M.P. Humphries, M. Salto-Tellez, J.A. James, M.G. Hanna, J.C. Melms, S. Vallabhaneni, K. Litchfield, I. Usaite, D. Biswas, R. Bareja, H.W. Li, M.L. Martin, P. Dorsaint, J.A. Cavallo, P. Li, C. Pauli, L. Gottesdiener, B.J. DiPardo, T.J. Hollmann, T. Merghoub, H.Y. Wen, J.S. Reis-Filho, N. Riaz, S.M. Su, A. Kalbasi, N. Vasan, S.N. Powell, J.D. Wolchok, O. Elemento, C. Swanton, A.N. Shoushtari, E.E. Parkes, B. Izar, S.F. Bakhoum, Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis, Cancer Discov, 11 (2021) 1212-1227.
[12]	J. He, H. Pan, W. Liang, D. Xiao, X. Chen, M. Guo, J. He, Prognostic Effect of Albumin-to-Globulin Ratio in Patients with solid tumors: A Systematic Review and Meta-analysis, J Cancer, 8 (2017) 4002-4010.
[13]	L.M. Coussens, Z. Werb, Inflammation and cancer, Nature, 420 (2002) 860-867.
[14]	S. Altarac, Cancer-associated serum globulin determined in patients with cervical, endometrial and ovarian cancer, Acta Med Croatica, 47 (1993) 19-22.
[15]	W. Jin, M. Zhu, Y. Zheng, Y. Wu, X. Ding, H. Wu, J. Ye, Y. Wu, Z. Zhu, X. Song, Perineural invasion, lactate dehydrogenase, globulin, and serum sodium predicting occult metastasis in oral cancer, Oral Dis, 28 (2022) 132-141.
[16]	U. Muller-Richter, C. Betz, S. Hartmann, R.C. Brands, Nutrition management for head and neck cancer patients improves clinical outcome and survival, Nutr Res, 48 (2017) 1-8.
[17]	F. Bozzetti, Z. Stanga, Does nutrition for cancer patients feed the tumour? A clinical perspective, Crit Rev Oncol Hematol, 153 (2020) 103061.
[18]	Y. Huang, S. Wei, N. Jiang, L. Zhang, S. Wang, X. Cao, Y. Zhao, P. Wang, The prognostic impact of decreased pretreatment haemoglobin level on the survival of patients with lung cancer: a systematic review and meta-analysis, BMC Cancer, 18 (2018) 1235.
[19]	R.K. Narayanaswamy, M. Potharaju, A.N. Vaidhyswaran, K. Perumal, Pre-radiotherapy Haemoglobin Level is A Prognosticator in Locally Advanced Head and Neck Cancers Treated with Concurrent Chemoradiation, J Clin Diagn Res, 9 (2015) XC14-XC18.
[20]	W. Zhou, C. Peng, Z. Liu, W. Cao, A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma, Eur Arch Otorhinolaryngol, 279 (2022) 391-398.
[21]	L. Quan, X. Jiang, X. Jia, F. Cheng, Prognostic Value of the Albumin-to-Globulin Ratio in Patients with Colorectal Cancer: A Meta-Analysis, Nutr Cancer, 74 (2022) 3329-3339.
[22]	X.S. Zhu, Y. Zhao, F.Y. Ma, S.K. Wu, Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy, Curr Med Sci, 42 (2022) 348-356.
[23]	M. Hayashi, D. Kobayashi, H. Takami, Y. Inokawa, N. Tanaka, K. Kurimoto, K. Nakanishi, S. Umeda, D. Shimizu, N. Hattori, M. Kanda, C. Tanaka, G. Nakayama, Y. Kodera, Albumin-Globulin Ratio Indicates the Survival Outcome of Pancreatic Cancer Cases Who Underwent Preoperative Treatment and Curative Surgical Resection, Nutr Cancer, 75 (2023) 1330-1339.
[24]	X. Zeng, G. Liu, Y. Pan, Y. Li, Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma, Front Oncol, 10 (2020) 146.
[25]	J. Zhang, Z. Lin, J. Zhou, Y. Huang, S. Chen, Y. Deng, M. Qiu, Y. Chen, Z. Hu, Effects of preoperative albumin-to-globulin ratio on overall survival and quality of life in esophageal cell squamous carcinoma patients: a prospective cohort study, BMC Cancer, 23 (2023) 342.
[26]	D. Callegaro, R. Miceli, S. Bonvalot, P. Ferguson, D.C. Strauss, A. Levy, A. Griffin, A.J. Hayes, S. Stacchiotti, C.L. Pechoux, M.J. Smith, M. Fiore, A.P. Dei Tos, H.G. Smith, L. Mariani, J.S. Wunder, R.E. Pollock, P.G. Casali, A. Gronchi, Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis, Lancet Oncol, 17 (2016) 671-680.
[27]	V.P. Balachandran, M. Gonen, J.J. Smith, R.P. DeMatteo, Nomograms in oncology: more than meets the eye, Lancet Oncol, 16 (2015) e173-180.

Predictive value of preoperative hemoglobin, albumin and globulin ratio in the prognosis of patients with oral squamous cell carcinoma

Knowledge

Abstract

Cite this article

share this article

References 27

Related Articles 2

Recommended Articles

Metrics

Comments

[1]	Yu XingFeng Shuang-Yue ZHANG. Expression and function of METTL5 in oral squamous cell carcinoma [J]. Oral Biomedicine, 2025, 16(1): 20-25.
[2]	. Research progress on FAM83A and its role in malignant tumors [J]. Oral Biomedicine, 2022, 13(2): 125-129.