Oral Biomedicine ›› 2025, Vol. 16 ›› Issue (3): 176-180.

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Periodontal Ligament Stem Cells: The Dual Role in Exosome-Mediated Periodontal Tissue Regeneration

  

  • Received:2024-08-23 Revised:2024-10-04 Online:2025-06-25 Published:2025-06-30

Abstract: Periodontal ligament stem cell(PDLSC), as a mesenchymal stem cell with multipotent differentiation capabilities, plays a critical role in periodontal tissue regeneration. Periodontal ligament stem cells promote bone formation, angiogenesis, and anti-inflammatory processes by secreting exosomes, and regulate their regenerative behavior through the uptake of exogenous exosomes. This review summarizes the recent advancements in research on periodontal ligament stem cells in exosome-mediated periodontal tissue regeneration and provides insights into their future applications.

Key words: Periodontitis, Periodontal ligament stem cells, Exosome, Periodontal tissue regeneration