Abstract: ［Abstract］Objective: To investigate the single nucleotide polymorphism with significant association on the head and neck cancer (HNC) risk in a Chinese Han population．Methods：We genotyped five variants (rs1494961, rs1229984, rs1789924, rs971074 and rs4767364) in a case-control study with 397 HNC cases and 900 controls, using the TaqMan allelic discrimination assay. Results：We found that rs1229984 at 4q23 significantly increased the risk of HNC [adjusted odds ratio (OR) =1.34, 95% con?dence interval (CI) = 1.05-1.71]. By contrast，no significant association was observed between the other four single nucleotide polymorphisms (SNPs) and HNC risk．Conclusion：These findings suggest that rs1229984 at 4q23 may serve as candidate marker for HNC susceptibility in a Chinese population.