Abstract: Advanced glycation end products (AGEs ) are formed by anonenzymatic glycation of proteins, initiated by a reaction between reducing sugars and free amino groups in lysine or arginine residues,which play a important role in the pathogenesis of diabetes (Diabetic mellitus, DM )complications. Inflammatory bone disease is common complication of diabetes, The mechanism of AGE s in bone destruction of diabetes is not clear, This reviewed try to elaborate the effects of AGE s in diabetes inflammatory bone disease, development, and the influence of oateoclasts/osteoblasts。