涎腺腺样囊性癌嗜神经侵袭相关神经营养因子研究进展

Abstract

Abstract: Adenoid cystic carcinoma is a very rare malignant tumor, accounting for 1% of head and neck malignancies, and approximately 10% of salivary tumors are adenoid cystic carcinoma. Adenoid cystic carcinoma has a slow growth process, but a high propensity for perineural invasion. Surgery is regarded as the main treatment for the disease. However, due to the nature of perineural invasion, it is difficult to obtain a clear surgical margin, resulting in postoperative recurrence and unfavorable prognosis. Therefore, it is particularly urgent to study the mechanism of perineural invasion systematically and comprehensively. In recent years, many researches on salivary adenoid cystic carcinoma have focused on the molecular mechanism of perineural invasion. This paper reviews the research progresses of neurotrophic factors, such as nerve growth factors, brain derived neurotrophic factor, glial cell derived neurotrophic factors and neurotrophic factor-3.

References

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Advance in neurotrophic factors promoting perineural invasion of salivary adenoid cystic carcinoma

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