Oral Biomedicine ›› 2023, Vol. ›› Issue (3): 197-201.

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Research progress of the mechanisms of concentrated growth factors in endodontic regeneration

  

  • Received:2022-07-01 Revised:2022-11-12 Online:2023-09-25 Published:2023-09-21
  • Contact: Yanxia Han E-mail:hanyanxia25@sina.com

Abstract: The primary goal of endodontic disease treatment is repairing and regenerating the damaged dental pulp tissue and restoring its natural function. Concentrated growth factor (CGF) is the latest generation of platelet concentrate product, constituted of a three-dimensional fibrin network and abundant growth factors, showing significant effects in tissue regeneration, therefore can be used as an effective bio-scaffold for dental pulp regeneration. The purpose of this review is to summarize the latest findings of the mechanisms of CGF in endodontic regeneration, thus providing theoretical support for further research and clinical application.

Key words: concentrated growth factors, dentin-pulp regeneration, angiogenesis, neurogenesis