Oral Biomedicine ›› 2024, Vol. 15 ›› Issue (3): 140-146.

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Effect of constitutive activation of β-catenin on initial healing of extraction sockets

  

  1. 1. Engineering Research Center of Tooth Restoration and Regeneration, Shanghai
    2. School of Dentistry Tongji University
    3.
    4. Department of Endodontics, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration
  • Received:2024-02-29 Revised:2024-03-22 Online:2024-06-25 Published:2024-07-04
  • Supported by:
    The role and mechanism of mitochondrial transfer of dental pulp stromal cells in Resolvin E1-mediated resolution of pulp inflammation and repair of pulp injury;The mechanism of pulp sensory nerve regulating the directional migration of DPSCs through CGRP/Ramp1 axis to promote dental pulp injury repair

Abstract: [Abstract] Objective:To investigate the effects of constitutive activation of β-catenin on the initial alveolar bone remodeling after tooth extraction. Methods: Catnblox(ex3)/+mice (control group) and DMP1-9.6kb-cre+/-;Catnblox(ex3)/+mice (experimental group) were constructed. The right maxillary first molar was extracted and were collected 1 week later. Histological stainings were performed to observe the healing of the extraction sockets. Results: Compared with the control group, TRAP staining of the experimental group showed a decrease in the number of osteoclasts (P<0.001), and Masson staining showed decreased collagen mineralization (P<0.01). Immunohistochemistry showed decreased specific staining for osteogenesis-related molecules OCN, DMP1, and OPG (P<0.01). Conclusion: Constitutive activation of β-catenin in DMP1-9.6kb-cre delays the initial healing rate of extraction sockets. [Key words] Extraction socket healing; Alveolar bone remodeling; β-catenin; Wnt/β-catenin signaling pathway;

Key words: [Key words] Extraction socket healing, Alveolar bone remodeling, β-catenin, Wnt/β-catenin signaling pathway

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