Abstract: Objective:? To explore the osteogenic potential and antioxidant ability of chlorogenic acid (CGA) coating on titanium surface in a high glucose environment. Methods:? A bioactive coating was formed on the titanium surface by grafting CGA using [3 - (2 - amino ethyl amino) - propyl] three oxygen radicals silane (AEAPTMS). The coating was characterized using scanning electron microscopy and a water contact angle instrument. Cell proliferation, adhesion to the coating, osteogenesis potential, and reactive oxygen species (ROS) generation capability were evaluated in MC3T3 E1 cell line under high glucose conditions prior to ossification. Results: The successful grafting of chlorogenic acid onto the titanium surface resulted in a highly hydrophilic coating. This coating effectively enhances cell proliferation and adhesion, while reducing ROS generation and promoting osteogenesis potential. Conclusions:? The chlorogenic acid coating on the titanium surface exhibits a potential to mitigate ROS generation and enhance osteogenesis in a high glucose environment.

Key words: Titanium implants, Chlorogenic acid, Diabetes, Osteogenic potential