慢性氟中毒对大鼠切牙釉质形态的影响

›› 2012, Vol. 3 ›› Issue (2): 71-73.

慢性氟中毒对大鼠切牙釉质形态的影响

刘盘龙¹,周红艳²,³,梅予锋⁴

1. 南京医科大学口腔研究所
2.
3. 江苏省儿童预防牙病科
4. 南京医科大学

收稿日期:2012-03-19 修回日期:2012-05-14 出版日期:2012-06-25 发布日期:2012-06-26
通讯作者: 梅予锋 E-mail:yf88mei@yahoo.com.cn
基金资助:
江苏省血地寄防应用性科研课题

Influences in enamel of rat incisor exposed to chronic fluorosis

Received:2012-03-19 Revised:2012-05-14 Online:2012-06-25 Published:2012-06-26

摘要/Abstract

摘要： 目的：观察慢性氟中毒下大鼠下颌切牙釉质形态改变，建立评价大鼠氟斑牙病变程度的方法。方法：将20只Wistar大鼠按性别随机分为4组，实验雌雄二组饮用浓度为100 mg/L的氟化钠双蒸水，对照雌雄二组单纯饮用双蒸水，观察8周。在自然光下，观察记录大鼠下颌切牙釉质形态改变，使用改良氟斑牙指数评价氟斑牙进展程度。结果：相比对照组，饮氟组大鼠随着氟暴露时间的增加，下颌切牙釉质透明度、光泽度及其受累范围等发生不同程度的变化；相同条件下，不同性别间氟斑牙指数无显著差异（P > 0.05）。结论：改良氟斑牙指数可以客观评价大鼠氟斑牙病变程度。

Abstract: Objective：To observe the changes in enamel of rat incisor under chronic fluorine poisoning，and establish a new index for evaluation of dental fluorosis in rat. Methods：20 Wistar rats were randomly divided into four groups by gender. Control groups were divided into male and female group, fed with double-distilled water. Fluorosis groups were fed with double-distilled water containing 100 mg/L of F﹣ for 8 weeks. Under natural light, the changes of the mandibular incisor enamel were recorded by digital camera. The progress of dental fluorosis was evaluated by an improved dental fluorosis index. Results：Compared with control group, the enamel of dental fluorosis changed in different degrees, such as clarity, glossiness, surface defects. The progress of dental fluorosis had a significantly increased by drinking fluoride time. Under the same condition, dental fluorosis index of the different genders had no significant difference in sex（P > 0.05）. Conclusions： The improved dental fluorosis index can be used to evaluate the severity of dental fluorosis in rats objectively.

刘盘龙周红艳梅予锋. 慢性氟中毒对大鼠切牙釉质形态的影响[J]. , 2012, 3(2): 71-73.