平阳霉素瘤内注射对婴幼儿血管瘤血清中血管内皮生长因子表达的影响

›› 2013, Vol. 4 ›› Issue (3): 138-141.

平阳霉素瘤内注射对婴幼儿血管瘤血清中血管内皮生长因子表达的影响

李向东¹,朱思超¹,杨锋²,常菊花¹,马培亚³

1. 山东省微山县人民医院口腔科
2. 徐州医学院口腔医学院
3. 中国人民解放军第九七医院烧伤整形外科中心

收稿日期:2013-09-02 修回日期:2013-09-10 出版日期:2013-09-25 发布日期:2013-10-22
通讯作者: 杨锋 E-mail:yangfeng0909@126.com

Influence of intratumoral injection of pingyangmycin on the expression of vascular endothelial growth factor in infantile hemangioma serum

Received:2013-09-02 Revised:2013-09-10 Online:2013-09-25 Published:2013-10-22

摘要/Abstract

摘要： 目的：探讨平阳霉素瘤内注射对婴幼儿增殖期血管瘤血清中血管内皮生长因子（vascular endothelial growth factor，VEGF）表达的影响及意义。方法：选取增殖期血管瘤婴幼儿23例，分别于平阳霉素瘤内注射治疗前及治疗后3、7、14 d时采集瘤内血，应用酶联免疫吸附（ELISA）法检测瘤内血清中VEGF的含量。结果：平阳霉素瘤内注射治疗后3 d和7 d时，瘤内血清中VEGF表达水平较治疗前明显降低（P < 0.05）；治疗后14 d时，瘤内血清中VEGF表达水平与治疗前相比，其差异无统计学意义（P > 0.05）。结论：平阳霉素瘤内注射治疗婴幼儿增殖期血管瘤，能明显降低瘤内血清中VEGF表达水平，但具有时效性；仅依此来评估婴幼儿血管瘤生长增殖速度及平阳霉素的治疗效果仍有待商榷。

Abstract: Objective：To explore clinical effect of intratumoral injection of pingyangmycin (PYM) on expression of vascular endothelial growth factor (VEGF) in infantile hemangioma serum in proliferative stage and its significance. Methods：23 infantile hemangioma cases in proliferative stage were enrolled to measure the content of VEGF in hemangioma serum by enzyme-linked immunosorbent assay (ELISA) before and 3 days,7 days,14 days after intralesional injection of PYM. Results：The expression of VEGF in hemangioma serum 3 days and 7 days after intralesional injection of PYM decreased significantly as compared to that before treatment (P<0.05), while there was no statistical difference between expression of VEGF in hemangioma serum 14 days after intralesional injection of PYM and that before injection (P>0.05). Conclusions：Intratumoral injection of pingyangmycin to treat infantile hemangioma in proliferative stage can obviously decrease expression of VEGF in hemangioma serum, but it has timeliness. It remains open to question to evaluate the growth rate of infantile hemangioma and clinical effectiveness of PYM for infantile hemangioma based on only the expression of VEGF in hemangioma serum.

李向东朱思超杨锋常菊花马培亚. 平阳霉素瘤内注射对婴幼儿血管瘤血清中血管内皮生长因子表达的影响[J]. , 2013, 4(3): 138-141.

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