涎腺腺样囊性癌嗜神经侵袭相关神经营养因子研究进展

摘要/Abstract

摘要： 腺样囊性癌是一种较少见的恶性肿瘤，占头颈部恶性肿瘤的1%，而在涎腺恶性肿瘤中约10%是腺样囊性癌。腺样囊性癌生长缓慢，但是神经浸润性强，手术是该病的主要治疗方法。然而，由于嗜神经侵袭的特性，很难获得清晰的手术边缘，导致术后复发和不良预后。因此，进一步系统、全面地研究嗜神经侵袭的机制尤为迫切。近年来许多对涎腺腺样囊性癌的研究重点都在嗜神经侵袭的分子机制上，本文就其中探索较多的神经营养因子：神经生长因子、脑源性神经营养因子、胶质细胞源性神经营养因子、神经营养因子-3的研究进展作一综述。

Abstract: Adenoid cystic carcinoma is a very rare malignant tumor, accounting for 1% of head and neck malignancies, and approximately 10% of salivary tumors are adenoid cystic carcinoma. Adenoid cystic carcinoma has a slow growth process, but a high propensity for perineural invasion. Surgery is regarded as the main treatment for the disease. However, due to the nature of perineural invasion, it is difficult to obtain a clear surgical margin, resulting in postoperative recurrence and unfavorable prognosis. Therefore, it is particularly urgent to study the mechanism of perineural invasion systematically and comprehensively. In recent years, many researches on salivary adenoid cystic carcinoma have focused on the molecular mechanism of perineural invasion. This paper reviews the research progresses of neurotrophic factors, such as nerve growth factors, brain derived neurotrophic factor, glial cell derived neurotrophic factors and neurotrophic factor-3.

房欢欢钟旖万林忠. 涎腺腺样囊性癌嗜神经侵袭相关神经营养因子研究进展[J]. , 2019, 10(1): 54-57.

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