他克莫司在肿瘤发生发展中的作用及相关机制研究

摘要/Abstract

摘要： 他克莫司（FK506）作为临床使用的强效免疫抑制剂，能够调节细胞增殖、分化相关信号等通路，尤其是调节活化T细胞核因子（NFAT）通路影响肿瘤的发生发展。他克莫司可能会起到抑癌或促癌的作用，而决定他克莫司对癌症作用结果的重要因素可能是肿瘤细胞中的“优势NFAT亚型”。另外，他克莫司与FK506结合蛋白（FKBP）结合亦可影响其他信号通路，其作用结果可能与他克莫司的剂量相关。

关键词: 他克莫司, 抑癌, 促癌, NFAT通路, FK506结合蛋白

严旭彤陈昕程芷兰刘海雯洪筠. 他克莫司在肿瘤发生发展中的作用及相关机制研究[J]. 口腔生物医学, 2020, 11(1): 63-66.

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他克莫司在肿瘤发生发展中的作用及相关机制研究

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