亚硝胺体内暴露水平及影响因素

doi:10.3969/j.issn.1674-8603.2020.02.001

摘要/Abstract

摘要： 硝酸盐-亚硝酸盐-一氧化氮体系在机体中发挥重要生理作用，在多系统中具有广泛的应用前景。亚硝胺是环境中常见的一类致癌物，与食管癌、胃癌等肿瘤的发生密切相关。亚硝酸盐作为亚硝胺的前体物，在特殊条件下可形成亚硝胺，其安全性受到广泛的关注，目前明确维生素C、维生素E等抗氧化剂和多酚类物质可抑制内源性亚硝胺的形成。本文将综述与亚硝酸盐相关亚硝胺的来源、致癌风险及其影响因素。

关键词: 亚硝胺, 亚硝酸盐, 硝酸盐, 食品

杨子王松灵. 亚硝胺体内暴露水平及影响因素[J]. 口腔生物医学, 2020, 11(2): 67-70.

参考文献 72

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[31]	Yurchenko S, Molder U.The occurrence of volatile N-nitrosamines in Estonian meat products[J].Food Chem, 2007, 100(4):1713-1721
[32]	Herrmann S S, Duedahl-Olesen L, Granby K.Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment[J]. Food Control, 2015, 48: 163-169.
[33]	Fong L Y Y, Nguyen V T, Farber J L.Esophageal cancer prevention in zinc-deficient rats: Rapid induction of apoptosis by replenishing zinc[J].JNCI, 2001, 93(20):1525-1533
[34]	D' ischia M, Panzella L, Manini P, et al.The chemical basis of the antinitrosating action of polyphenolic cancer chemopreventive agents[J].Curr Med Chem, 2006, 13(26):3133-3144
[35]	Mirvish S S, Davis M E, Lisowyj M P, et al.Effect of feeding nitrite,ascorbate,hemin,and omeprazole on excretion of fecal total apparent N-Nitroso compounds in mice[J].Chem Res Toxicol, 2008, 21(12):2344-2351
[36]	Choi S Y, Chung M J, Sung N J.Volatile N-nitrosamine inhibition after intake Korean green tea and maesil (Prunus mume SIEBet ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate[J].Food Chem Toxicol, 2002, 40(7):949-957
[37]	Lundberg J O, Carlstrom M, Weitzberg E.Metabolic effects of dietary nitrate in health and disease[J].Cell Metab, 2018, 28(1):9-22
[38]	Jakszyn P, Bingham S, Pera G, et al.Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study[J].Carcinogenesis, 2006, 27(7):1497-1501
[39]	Gushgari A J, Halden R U.Critical review of major sources of human exposure to N-nitrosamines[J]. Chemosphere, 2018, 210: 1124-1136.
[40]	Ma L S, Hu L, Feng X Y, et al.Nitrate and nitrite in health and disease[J].Aging Dis, 2018, 9(5):938-945
[41]	Qiu Y S, Chen J H, Yu W J, et al.Contamination of Chinese salted fish with volatile N-nitrosamines as determined by QuEChERS and gas chromatography-tandem mass spectrometry[J]. Food Chem, 2017, 232: 763-769.
[42]	De Mey E, De Maere H, Paelinck H, et al.Volatile N-nitrosamines in meat products: Potential precursors,influence of processing,and mitigation strategies[J].Crit Rev Food Sci, 2017, 57(13):2909-2923
[43]	Scheeren M B, Sabik H, Gariepy C, et al.Determination of N-nitrosamines in processed meats by liquid extraction combined with gas chromatography-methanol chemical ionisationmass spectrometry[J].Food Addit Contam A, 2015, 32(9):1436-1447
[44]	Weitzberg E, Lundberg J O: Novel Aspects of Dietary Nitrate and Human Health, Cousins R J, editor, Annu Rev Nutr, Vol 33, 2013: 129-159.
[45]	Gassara F, Kouassi A P, Brar S K, et al.Green Alternatives to Nitrates and Nitrites in Meat-based Products-A Review[J].Crit Rev Food Sci, 2016, 56(13):2133-2148
[46]	颜云荞, 吴婷婷, 冉昇, 等.我国与CAC关于食品中亚硝酸盐限量标准的对比分析[J]. 中国食品添加剂, 2012(4): 235-240.
[47]	Herrmann S S, Duedahl-Olesen L, Christensen T, et al.Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark[J]. Food Chem Toxicol, 2015, 80: 137-143.
[48]	Jakszyn P, Agudo A, Berenguer A, et al.Intake and food sources of nitrites and N-nitrosodimethylamine in Spain[J].Public Health Nutr, 2006, 9(6):785-791
[49]	Archer D L.Evidence that ingested nitrate and nitrite are beneficial to health[J].J Food Protect, 2002, 65(5):872-875
[50]	Keszei A P, Goldbohm R A, Schouten L J, et al.Dietary N-nitroso compounds,endogenous nitrosation,and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study[J].Am J Clin Nutr, 2013, 97(1):135-146
[51]	Hughes R, Cross A J, Pollock J R A, et al.Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation[J].Carcinogenesis, 2001, 22(1):199-202
[52]	Zeilmaker M J, Bakker M I, Schothorst R, et al.Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals[J].Toxicol Sci, 2010, 116(1):323-335
[53]	Bingham S A, Pignatelli B, Pollock J R A, et al.Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?[J].Carcinogenesis, 1996, 17(3):515-523
[54]	Loh Y H, Jakszyn P, Luben R N, et al.N-nitroso compounds and cancer incidence: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study[J].Am J Clin Nutr, 2011, 93(5):1053-1061
[55]	Cross A J, Pollock J R A, Bingham S A.Haem,not protein or inorganic iron,is responsible for endogenous intestinal N-nitrosation arising from red meat[J].Cancer Res, 2003, 63(10):2358-2360
[56]	Wei F, Xu X L, Zhou G H, et al.Irradiated Chinese rugao ham: changes in volatile N-nitrosamine,biogenic amine and residual nitrite during ripening and post-ripening[J].Meat Sci, 2009, 81(3):451-455
[57]	余卫军, 邱月升, 王佩, 等.气相色谱-三重四极杆质谱测定广东地区市售腊肠中种挥发性亚硝胺[J].肉类研究, 2016, 30(6):29-34
[58]	Fan C C, Lin T F.N-nitrosamines in drinking water and beer: Detection and risk assessment[J]. Chemosphere, 2018, 200: 48-56.
[59]	Edwards S H, Rossiter L M, Taylor K M, et al.Tobacco-specific Nitrosamines in the tobacco and mainstream smoke of US commercial cigarettes[J].Chem Res Toxicol, 2017, 30(2):540-551
[60]	Herrmann S S, Granby K, Duedahl-Olesen L.Formation and mitigation of N-nitrosamines in nitrite preserved cooked sausages[J]. Food Chem, 2015, 174: 516-526.
[61]	Xian Y P, Wu Y L, Dong H, et al.Ice-bath assisted sodium hydroxide purification coupled with GC-MS/MS analysis for simultaneous quantification of ethyl carbamate and 12 N-nitrosoamines in yellow rice wine and beer[J]. Food Chem, 2019, 300.
[62]	Pobel D, Riboli E, Cornee J, et al.Nitrosamine,nitrate and nitrite in relation to gastric-cancer-A case-control study in marseilles,France[J].Eur J Epidemiol, 1995, 11(1):67-73
[63]	Cross A J, Freedman N D, Ren J S, et al.Meat consumption and risk of esophageal and gastric cancer in a large prospective study[J].Am J Gastroenterol, 2011, 106(3):432-442
[64]	Knekt P, Jarvinen R, Dich J, et al.Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate,nitrite and N-nitroso compounds: A follow-up study[J].Int J Cancer, 1999, 80(6):852-856
[65]	Hernandez-Ramirez R U, Galvan-Portillo M V, Ward M H, et al.Dietary intake of polyphenols,nitrate and nitrite and gastric cancer risk in Mexico City[J].Int J Cancer, 2009, 125(6):1424-1430
[66]	Dellavalle C T, Xiao Q, Yang G, et al.Dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study[J].Int J Cancer, 2014, 134(12):2917-2926
[67]	Yurchenko S, Molder U.The occurrence of volatile N-nitrosamines in Estonian meat products[J].Food Chem, 2007, 100(4):1713-1721
[68]	Herrmann S S, Duedahl-Olesen L, Granby K.Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment[J]. Food Control, 2015, 48: 163-169.
[69]	Fong L Y Y, Nguyen V T, Farber J L.Esophageal cancer prevention in zinc-deficient rats: Rapid induction of apoptosis by replenishing zinc[J].JNCI, 2001, 93(20):1525-1533
[70]	D' ischia M, Panzella L, Manini P, et al.The chemical basis of the antinitrosating action of polyphenolic cancer chemopreventive agents[J].Curr Med Chem, 2006, 13(26):3133-3144
[71]	Mirvish S S, Davis M E, Lisowyj M P, et al.Effect of feeding nitrite,ascorbate,hemin,and omeprazole on excretion of fecal total apparent N-Nitroso compounds in mice[J].Chem Res Toxicol, 2008, 21(12):2344-2351
[72]	Choi S Y, Chung M J, Sung N J.Volatile N-nitrosamine inhibition after intake Korean green tea and maesil (Prunus mume SIEBet ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate[J].Food Chem Toxicol, 2002, 40(7):949-957

亚硝胺体内暴露水平及影响因素

The exposure level of nitrosamine in vivo and influencing factors

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