外泌体在颞下颌关节软骨再生中的应用前景

口腔生物医学 ›› 2021, Vol. 12 ›› Issue (1): 53-57.

外泌体在颞下颌关节软骨再生中的应用前景

王淋,田卫东

口腔转化医学教育部工程中心（四川大学），口腔再生医学国家地方联合工程实验室（四川大学），口腔疾病研究国家重点实验室（四川大学），国家口腔疾病临床医学研究中心（四川大学），四川大学华西口腔医院创伤整形外科

收稿日期:2021-01-20 修回日期:2021-02-07 出版日期:2021-03-25 发布日期:2021-04-01
通讯作者: 田卫东 E-mail:drtwd@sina.com
基金资助:
国家重点研发计划（2017YFA0104800）

Application of tissue engineering in the treatment of temporomandibular joint osteoarthritis

Received:2021-01-20 Revised:2021-02-07 Online:2021-03-25 Published:2021-04-01
Contact: Wei-Dong TIAN E-mail:drtwd@sina.com

摘要/Abstract

摘要： 颞下颌关节（TMJ）骨性关节炎是由各种原因导致的软骨细胞死亡、软骨基质降解以及软骨下骨破坏所引起。基于间充质干细胞（MSC）的细胞疗法为TMJ软骨再生带来了新的希望，MSC外泌体介导的软骨组织再生技术可以克服MSC扩增时的去分化、植入后再生效率低下以及免疫排斥反应等。本综述介绍了TMJ的结构特点、软骨退化机制、MSC外泌体和应用，并探讨了MSC外泌体在TMJ软骨再生中的应用前景。

关键词: 颞下颌关节骨关节炎, 外泌体, 间充质干细胞, 软骨再生

王淋田卫东. 外泌体在颞下颌关节软骨再生中的应用前景[J]. 口腔生物医学, 2021, 12(1): 53-57.

Wei-Dong TIAN. Application of tissue engineering in the treatment of temporomandibular joint osteoarthritis[J]. Oral Biomedicine, 2021, 12(1): 53-57.

参考文献 46

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外泌体在颞下颌关节软骨再生中的应用前景

Application of tissue engineering in the treatment of temporomandibular joint osteoarthritis

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