Abstract: Extracellular vesicle (EV) are membranous vesicles that occur naturally in organisms and are used for intercellular communication. They can induce an appropriate immune microenvironment to promote tissue regeneration by regulating immune cells. In this paper, we reviewed the regulation of immune function by EV under different conditions and the role and mechanism of immune microenvironment under THE action of EV in tissue repair, with emphasis on the immune regulation function of MESenchymal stem cells-derived EV.