初级纤毛调节干细胞分化促进骨发育的研究进展

摘要/Abstract

摘要： 初级纤毛作为信号传感器，存在于大多数哺乳动物细胞表面，干细胞表面的初级纤毛通过感知化学、机械、生物等多种信号感在维持细胞干性、介导细胞谱系分化过程中发挥重要作用。初级纤毛结构或功能异常可导致纤毛病，导致颅颌面发育异常、长骨发育障碍等骨骼相关表型异常。本文旨在整合初级纤毛在骨骼系统发育相关干细胞领域内的相关研究工作，聚焦于初级纤毛对骨骼发育相关干细胞的精细调控作用，以期为干细胞治疗及组织工程再生提供一个新的潜在治疗靶点。

关键词: 初级纤毛, 骨骼干细胞, 骨发育, 损伤修复, 信号传导

Key words: primary cilia, skeletal development, repair, singal transduction

张蕾陶狄坷孙瑶. 初级纤毛调节干细胞分化促进骨发育的研究进展[J]. 口腔生物医学, 2022, 13(4): 255-260.

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初级纤毛调节干细胞分化促进骨发育的研究进展

Research progress of primary cilia in regulating stem cell differentiation and promoting bone development

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