口腔中复合树脂材料生物降解的研究进展

口腔生物医学 ›› 2022, Vol. 13 ›› Issue (4): 261-264.

口腔中复合树脂材料生物降解的研究进展

于依岩¹,张志民¹,赵洪岩²

1. 吉林大学口腔医学院
2. 吉林大学口腔医院牙体牙髓病科

收稿日期:2022-02-28 修回日期:2022-11-23 出版日期:2022-12-25 发布日期:2022-12-24
通讯作者: 赵洪岩 E-mail:1973hero@163.com
基金资助:
吉林省卫生健康科技能力提升项目

Research progress in the biodegradation of composite resins applied in oral cavity.

Received:2022-02-28 Revised:2022-11-23 Online:2022-12-25 Published:2022-12-24

摘要/Abstract

摘要： 复合树脂是口腔临床工作中重要的材料之一，主要应用于牙体缺损的修复，粘接等方面。但是其内含的单体之一双酚A-双甲基丙烯酸缩水甘油酯（bisphenol A diglycidylmethacrylate, bisGMA）很容易被来自细菌以及唾液中的酯酶降解，产生副产物双羟丙氧基苯基丙烷（Bishydroxypropoxyphenyl propane，bisHPPP）进而影响患者修复体的使用寿命，这就称为复合树脂的生物降解。因此，本文系统地就复合树脂生物降解的原因，机制，在不同口腔材料中的应用以及如何避免进行综述，为临床中使用复合树脂提供指导。

关键词: 复合树脂, 酯酶, 生物降解, 变形链球菌, 树脂粘接剂, SMU-118c

Abstract: Composite resins is one of the important materials in stomatology which mainly applied in rest-oration of tooth defect、dental adhesives and so forth. However, it is fact that bisphenol A diglycidylmeth-acrylate (bisGMA) existed in composite resins can be biodegraded by esterase from bacteria and saliva, releasing the by-product named bishydroxypropoxyphenyl propane (bisHPPP), thus decreasing the life span of restoration. The article provides reasons, mechanism of composite resins biodegradation, rewiewing application in the different material and giving method to alleviate biodegradation, which will provide help in the use of composite resins.

Key words: Composite resins, Esterases, Biodegradation, Streptococcus mutans, Dental adhesive, SMU-118c, Composite resins, Esterases, Biodegradation, Streptococcus mutans, Dental adhesive, SMU-118c

于依岩张志民赵洪岩. 口腔中复合树脂材料生物降解的研究进展[J]. 口腔生物医学, 2022, 13(4): 261-264.

参考文献 33

[1]	Ferracane JL.Resin composite--state of the art[J].Dent Mater, 2011, 27(1):29-38
[2]	Gitalis R, Bae JH, Preston M, et al.Human neutrophils compromise the restoration-tooth interface[J].Acta Biomater, 2020, 117( ):283-293
[3]	Huang B, Siqueira WL, Cvitkovitch DG, et al.Esterase from a cariogenic bacterium hydrolyzes dental resins[J].Acta Biomater, 2018, 71:330-338
[4]	Chang MC, Lin LD, Chuang FH, et al.Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity[J].Acta Biomater, 2012, 8(3):1380-1387
[5]	Nedeljkovic I, De Munck J, Ungureanu AA, et al.Biofilm-induced changes to the composite surface[J].J Dent, 2017, 63:36-43
[6]	Spencer P, Ye Q, Misra A, et al.Proteins,pathogens,and failure at the composite-tooth interface[J].J Dent Res, 2014, 93(12):1243-1249
[7]	Huang B, Sadeghinejad L, Adebayo OIA, et al.Gene expression and protein synthesis of esterase from Streptococcus mutans are affected by biodegradation by-product from methacrylate resin composites and adhesives[J].Acta Biomater, 2018, 81:158-168
[8]	Marashdeh MQ, Gitalis R, Levesque C, et al.Enterococcus faecalis Hydrolyzes Dental Resin Composites and Adhesives[J].J Endod, 2018, 44(4):609-613
[9]	Soehnlein O, Steffens S, Hidalgo A, et al.Neutrophils as protagonists and targets in chronic inflammation[J].Nat Rev Immunol, 2017, 17(4):248-261
[10]	Gitalis R, Zhou L, Marashdeh MQ, et al.Human neutrophils degrade methacrylate resin composites and tooth dentin[J].Acta Biomater, 2019, 88:325-331
[11]	Shokati B, Tam LE, Santerre JP, et al.Effect of salivary esterase on the integrity and fracture toughness of the dentin-resin interface[J].J Biomed Mater Res B Appl Biomater, 2010, 94(1):230-237
[12]	Finer Y, Jaffer F, Santerre JP.Mutual influence of cholesterol esterase and pseudocholinesterase on the biodegradation of dental composites[J].Biomaterials, 2004, 25(10):1787-1793
[13]	Stewart CA, Finer Y.Biostable,antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions[J].Dent Mater, 2019, 35(1):36-52
[14]	Huang B, Cvitkovitch DG, Santerre JP, et al.Biodegradation of resin-dentin interfaces is dependent on the restorative material, mode of adhesion, esterase or MMP inhibition [J]. Dent Mater, 2018 34 (9): 1253-1262.[J].Dent Mater, 2018, 34(9):1253-1262
[15]	Skaff O, Pattison DI, Davies MJ.The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study[J].Biochemistry, 2008, 47(31):8237-8245
[16]	汪嘉, 何智妍, 冉淑君.耐氟变形链球菌对树脂-牙本质粘接强度的影响[J].上海口腔医学, 2018, 27(3):239-243
[17]	Serkies KB, Garcha R, Tam LE, et al.Matrix metalloproteinase inhibitor modulates esterase-catalyzed degradation of resin-dentin interfaces [J]. Dent Mater, 2016 32(12): 1513-1523.
[18]	郭馨蔚.变形链球菌及其耐氟菌株对CAD/CAM陶瓷粘接的影响 [D]; 吉林大学, 2020.
[19]	Mainjot AK, Dupont NM, Oudkerk JC, et al.From Artisanal to CAD-CAM Blocks: State of the Art of Indirect Composites[J].J Dent Res, 2016, 95(5):487-495
[20]	郭馨蔚, 张志民, 赵洪岩.陶瓷材料的分类及研究进展[J].口腔生物医学, 2019, 10(02):109-113
[21]	Lambert H, Durand JC, Jacquot B, et al.Dental biomaterials for chairside CADCAM: State of the art[J].J Adv Prosthodont, 2017, 9(6):486-495
[22]	Stewart CA, Hong JH, Hatton BD, et al.Antimicrobial antidegradative dental adhesive preserves restoration-tooth bond[J].Dent Mater, 2020, 36(12):1666-1679
[23]	Delaviz Y, Nascimento MA, Laschuk MW, et al.Synthesis and characterization of Ciprofloxacin-containing divinyl oligomers and assessment of their biodegradation in simulated salivary esterase[J].Dent Mater, 2018, 34(5):711-725
[24]	Cherchali FZ, Attik N, Mouzali M, et al.Structural stability of DHMAI antibacterial dental composite following in vitro biological aging[J].Dent Mater, 2020, 36(9):1161-1169
[25]	Salmanli M, Tatar Yilmaz G, Tuzuner T.Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches[J].Comput Methods Programs Biomed, 2021, 212:106454-
[26]	Sun S, Wang GL, Huang Y, et al.The effects of 2-hydroxyethyl methacrylate on matrix metalloproteinases 2 and 9 in human pulp cells and odontoblast-like cells in vitro[J].Int Endod J, 2018, 51 Suppl 2:157-
[27]	Delaviz Y, Finer Y, Santerre JP.Biodegradation of resin composites and adhesives by oral bacteria and saliva: a rationale for new material designs that consider the clinical environment and treatment challenges[J].Dent Mater, 2014, 30(1):16-32
[28]	Chaussain-Miller C, Fioretti F, Goldberg M, et al.The role of matrix metalloproteinases (MMPs) in human caries[J].J Dent Res, 2006, 85(1):22-32
[29]	Bourgi R, Daood U, Bijle MN, et al.Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry [J]. Polymers (Basel), 2021, 13(5).
[30]	Phan AC, Tang ML, Nguyen JF, et al.High-temperature high-pressure polymerized urethane dimethacrylate-mechanical properties and monomer release[J].Dent Mater, 2014, 30(3):350-356
[31]	Delaviz Y, Yang M, Santerre JP.Biodegradation Studies of Novel Fluorinated Di-Vinyl Urethane Monomers and Interaction of Biological Elements with Their Polymerized Films [J]. Polymers (Basel), 2017, 9(8).
[32]	Liao Y, Brandt BW, Li J, et al.Fluoride resistance in Streptococcus mutans: a mini review[J].J Oral Microbiol, 2017, 9(1):1344509-
[33]	Zhu L, Zhang Z, Liang J.Fatty-acid profiles and expression of the fabM gene in a fluoride-resistant strain of Streptococcus mutans[J].Arch Oral Biol, 2012, 57(1):10-14