m6A甲基化调控骨质疏松症的研究进展

摘要/Abstract

摘要： 骨质疏松症（OP）是当前常见的一类骨性疾病，且被认为具有高度的遗传性。N6-甲基腺嘌呤（m6A）是RNA甲基化修饰中的重要组成部分，是真核生物中最常见的一种动态可逆的修饰过程，是表观遗传修饰的重要组成部分。本文总结了m6A甲基修饰的研究进展，对文献报道中甲基转移酶样（METTL）3、METTL14、肥胖相关酶（FTO）等m6A修饰相关蛋白在OP的发生、发展、治疗过程中的作用进行系统性综述，旨在为OP的机制研究及治疗提供新的思路。

关键词: 骨质疏松症, N6- 甲基腺嘌呤, 甲基化修饰

Key words: osteoporosis, osteoporosis, methylated modification

田佳欧阳仁俊林雪杨晓红. m6A甲基化调控骨质疏松症的研究进展[J]. 口腔生物医学, 2022, 13(4): 265-269.

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