口腔生物医学 ›› 2023, Vol. 14 ›› Issue (2): 123-127.
汪泽琪,郑吉吉,梁兰仱,吴家媛*
收稿日期:2022-06-21
修回日期:2023-05-16
出版日期:2023-06-25
发布日期:2023-07-31
通讯作者:
吴家媛
E-mail:wujiayuan@zmdu.com.cn
基金资助:
Received:2022-06-21
Revised:2023-05-16
Online:2023-06-25
Published:2023-07-31
摘要： 整合素（ITG）是细胞胞膜表面重要的黏附分子家族成员之一，具备细胞与胞外基质、细胞与细胞之间的双向信号介导作用。其异二聚体ITGα2具有明显的促进细胞黏附、抑制血管生成作用和良好的成骨诱导能力。本文对ITGα2在细胞生物学性能、干细胞干性维持及分化、血管生成调节等方面的作用及其相应机制进行文献综述。
汪泽琪 吴家媛 郑吉吉. 整合素α2的研究进展[J]. 口腔生物医学, 2023, 14(2): 123-127.
| [1] | Ku?elová K, Obr A, Marková J, et al.Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: Impact of NPM1 and FLT3 mutations[J].Eur J Haematol, 2020, 105(5):578-587 |
| [2] | Pulous FE, Grimsley-Myers CM, Kansal S, et al.Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function[J].Circ Res, 2019, 124(6):891-903 |
| [3] | Roche F, Sipil? K, Honjo S, et al.Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin[J].Matrix Biol, 2015, 48:89-99 |
| [4] | Kunicki TJ, Orchekowski R, Annis D, et al.Variability of integrin alpha 2 beta 1 activity on human platelets[J].Blood, 1993, 82(9):2693-2703 |
| [5] | Douglass S, Goyal A, Iozzo RV.The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy[J].Connect Tissue Res, 2015, 56(5):381-391 |
| [6] | Eapen A, Ramachandran A, George A.Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells[J].J Biol Chem, 2012, 287(8):5211-5224 |
| [7] | Heino J.Cellular signaling by collagen-binding integrins[J].Adv Exp Med Biol, 2014, 819:143-155 |
| [8] | Cheli Y, Kanaji S, Jacquelin B, et al.Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2[J]. Biochim Biophys Acta. 2007，1769(9-10):546e558 |
| [9] | GANGULY K K, PAL S, MOULIK S, et al.Integrins and metastasis[J].Cell Adhesion Migr, 2013, 7(3):251-261 |
| [10] | Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC.Structural basis of collagen recognition by integrin alpha2- beta1[J]. Cell. 2000; 101(1):47e56 |
| [11] | Kamata T, Liddington RC, Takada Y (1999) Interaction between collagen and the alpha(2) I-domain of integrin alpha(2)beta(1).Critical role of conserved residues in the metal ion-dependent adhesion site (MIDAS) region. J Biol Chem[J]. 274:32108–32111 |
| [12] | Goyal A, Poluzzi C, Willis CD, et al.Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)- evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1alpha and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation[J].J Biol Chem, 2012, 287:43543-43556 |
| [13] | Klekotka PA, Santoro SA, Zutter MM.alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK[J].J Biol Chem, 2001, 276:9503-9511 |
| [14] | Ivaska J, Reunanen H, Westermarck J, et al.Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail[J]. J Cell Biol.1999, 147(2):401-416. |
| [15] | Naci D, Aoudjit F.Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways[J]. Cell Signal.2014, 26(9):2008-2015. |
| [16] | Lu PW, Li L, Wang F, et al.Inhibitory role of large intergenic noncoding RNA-ROR on tamoxifen resistance in the endocrine therapy of breast cancer by regulating the PI3K/Akt/mTOR signaling pathway[J].J Cell Physiol.2019, 234(2):1904-1912. |
| [17] | Mar?dziak M, Tomaszewski K, Polinceusz P, et al.Static magnetic field enhances the viability and proliferation rate of adipose tissue-derived mesenchymal stem cells potentially through activation of the phosphoinositide 3-kinase/Akt (PI3K/Akt) pathway[J]. Electromagn Biol Med.2017, 36(1):45-54. |
| [18] | Sarkar S, Svoboda M, de Beaumont R, et al.The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells[J]. Leuk Lymphoma. 2002, 43(8):1663-1671. |
| [19] | Ivaska J, Nissinen L, Immonen N, et al.Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta[J]. Mol Cell Biol.2002, 22:1352–1359 |
| [20] | Howden JD, Michael M, Hight-Warburton W, et al.α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions[J]. BMC Biol.2021, 19(1):130. |
| [21] | Etoh T, Thomas L, Pastel-Levy C, et al.Role of integrin alpha 2 beta 1 (VLA-2) in the migration of human melanoma cells on laminin and type IV collagen[J]. J Invest Dermatol.1993; 100(5):640e647. |
| [22] | 胡若文, 陈晓芳.整合素和-钙黏素在诱导多能干细胞重编程及干性维持中的作用[J].中国组织工程研究, 2018, 22(29):4698-4705 |
| [23] | Shih YR, Tseng KF, Lai HY, et al.Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells[J]. J Bone Miner Res.2011, 26(4):730-738. |
| [24] | Wei T, Li J, Sun H, et al.Verification of osteoblast differentiation on airborne-particle abrasion, large-grit, acid-etched surface of titanium implants regulated by yes-associated protein and transcriptional coactivator with PDZ-binding motif[J].J Oral Sci.2019, 61(3):431-440. |
| [25] | Leem YH, Lee KS, Kim JH, et al.Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs[J].J Tissue Eng Regen Med, 2016, 10(10):E527-E536 |
| [26] | 张岩, 陶海荣, 何耀华, 等.镁锌合金对成骨细胞整合素表达的影响[J].中华实验外科杂志, 2010, （05）:640-642 |
| [27] | Hu HM, Yang L, Wang Z, et al.Overexpression of integrin a2 promotes osteogenic differentiation of hBMSCs from senile osteoporosis through the ERK pathway[J].Int J Clin Exp Pathol, 2013, 6(5):841-852 |
| [28] | Su YJ, Lin WH, Chang YW, et al.Polarized cell migration induces cancer type-specific CD133integrinSrcAktGSK3ββ-catenin signaling required for maintenance of cancer stem cell properties[J].Oncotarget, 2015, 6(35):38029-38045 |
| [29] | Adorno-Cruz V, Liu H.Regulation and functions of integrin α2 in cell adhesion and disease[J].Genes Dis, 2019, 6(1):16-24 |
| [30] | Saarialho-Kere UK, Kovacs SO, Pentland AP, et al.Cellmatrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing[J].J Clin Invest, 1993, 92:2858-2866 |
| [31] | Pilcher BK, Dumin JA, Sudbeck BD, et al.Parks WC The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix[J].J Cell Biol, 1997, 137:1445-1457 |
| [32] | Messent AJ, Tuckwell DS, Knauper V, et al.Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion[J].J Cell Sci, 1998, 111(Pt 8):1127-1135 |
| [33] | Xia H, Seeman J, Hong J, et al.Low alpha(2)beta(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the beta-catenin pathway[J].Am J Pathol, 2012, 181:222-233 |
| [34] | Richter M, Ray SJ, Chapman TJ et al.Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection[J].J Immunol, 2007, 178:4506-4516 |
| [35] | Zweers MC, Davidson JM, Pozzi A, et al.Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization[J].J Invest Dermatol, 2007, 127(2):467-478 |
| [36] | McCall-Culbreath KD, Li Z, Zutter MM.Crosstalk between the alpha2beta1 integrin and c-metHGF-R regulates innate immunity[J].Blood, 2008, 111(7):3562-3570 |
| [37] | Gagliani N, Magnani CF, Huber S, et al.Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells[J].Nat Med, 2013, 19(6):739-746 |
| [38] | 马玉, 段子文, 李淑慧, 等.牙周膜干细胞与根尖乳头干细胞成骨及成牙本质能力比较的实验研究[J].口腔医学, 2018, 38(01):5-9 |
| [39] | Ojalill M, Parikainen M, Rappu P, et al.Integrin α2β1 decelerates proliferation,but promotes survival and invasion of prostate cancer cells[J].Oncotarget, 2018, 9(65):32435-32447 |
| [40] | Hall CL, Dubyk CW, Riesenberger TA, et al.Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase[J].Neoplasia, 2008, 10(8):797-803 |
| [41] | Ramirez NE, Zhang Z, Madamanchi A, et al.O’Rear LD,Nashabi A,Li Z,Dupont WD,Zijlstra A,Zutter MM The a2b1 integrin is a metastasis suppressor in mouse models and human cancer[J].J Clin Invest, 2011, 121:226-237 |
| [42] | Wong KF, Liu AM, Hong W, et al.Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma[J].Oncotarget, 2016, 7(47):77683-77695 |
| [43] | Bartolomé RA, Barderas R, Torres S, et al.Cadherin-17 interacts with a2b1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis[J].Oncogene, 2013, 33:1658-1669 |
| [44] | Van de Walle GR, Vanhoorelbeke K, Majer Z, et al.Two functional active conformations of the integrin {alpha}2{beta}1,depending on activation condition and cell type[J].J Biol Chem, 2005, 280:36873-36882 |
| [45] | Borza CM, Su Y, Chen X, et al.Inhibition of integrin alpha2beta1 ameliorates glomerular injury[J]. J Am Soc Nephrol 2012, 23:1027–1038 |
| [46] | Nissinen L, Pentik?inen OT, Jouppila A, et al.A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy[J].Thromb Haemost, 2010, 103:387-397 |
| [47] | Ito K, Semba T, Uenaka T, et al.Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models[J].Cancer Sci, 2014, 105(8):1023-1031 |
| [48] | Liu F, Tong D, Li H, et al.Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2β5FAK signaling pathway[J].Oncotarget, 2016, 7(8):8896-8907 |
| [49] | Arlinghaus FT, Momic T, Ammar NA, et al.Identification of α2β1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae[J].Toxicon, 2013, 64:96-105 |
| [50] | Sonoyama W, Liu Y, Yamaza T, et al.Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study[J].J Endod, 2008, 34(2):166-171 |
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