牙齿形态发育调控关键机理的研究进展

摘要/Abstract

摘要： 牙发育过程是一个由复杂的信号分子级联网络精密调控上皮和间充质相互作用和诱导分化的器官发生过程。本文从牙齿形态发生不同阶段牙胚上皮和间充质细胞命运改变的视角出发，对近年来牙齿发育过程中形态调控的相关研究进展作一综述，以期增进对器官发育和形态发生的认识，为牙再生过程中精准调控再生牙形态提供思路和参考。

关键词: 牙发育, 形态发生, 上皮间充质相互作用, 信号分子

Abstract: Tooth development is an organogenetic process in which epithelial-mesenchymal interactions and differentiation are precisely regulated by a complex cascade network of signaling molecules. In this paper, from the perspective of the changes in the fate of dental germ epithelial and mesenchymal cells in different stages of tooth morphogenesis, the research progress of morphological regulation during tooth development in recent years is reviewed, in order to improve the understanding of organ development and morphogenesis, and provide ideas and references for precise regulation of the regenerated tooth morphology during tooth regeneration.

Key words: tooth development, morphogenesis, epithelial-mesenchymal interaction, signaling molecules

徐小乔巩旭燕张晗孙瑶. 牙齿形态发育调控关键机理的研究进展[J]. 口腔生物医学, 2022, 13(3): 185-190.

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