粪肠球菌铁稳态维持对其生存和致病性影响的研究进展

摘要/Abstract

摘要： 粪肠球菌（E. faecalis）是一种革兰氏阳性细菌，是引起难治性根尖周炎的主要细菌微生物。铁是E. faecalis生存必不可少的微量元素，为了获取宿主铁，E. faecalis进化出多种机制，并且还可耐受对大多数细菌有毒性的高铁浓度。E. faecalis能够感知环境中铁水平的变化，并作出相应调整，这使得其能够在不同宿主生态位中成长并引发感染，因此本文综述了E. faecalis铁稳态的维持机制、铁稳态维持对E. faecalis致病性的影响以及通过调节铁稳态抑制E. faecalis活性的相关研究进展，为防治根尖周炎等感染性疾病提供理论依据?

关键词: 粪肠球菌, 铁, 铁稳态

Abstract: Enterococcus faecalis, a Gram-positive bacterium, is the leading cause of refractory periapical periodontitis. Iron is an essential micronutrient for E. faecalis to survive. To obtain iron from its host, E. faecalis has evolved a variety of mechanisms, and it can tolerate high iron concentrations that are toxic to any other bacteria. E. faecalis is able to sense changes in iron levels in the environment and adjust accordingly, enabling it to grow in different host niches and initiate infection, in this review, the mechanism of maintaining iron homeostasis, the effect of iron homeostasis on the pathogenicity of E. faecalis and the research progress of inhibiting E. Faecalis by regulating iron homeostasis were reviewed, to provide theoretical basis for the prevention and treatment of infectious diseases such as periapical periodontitis.

Key words: Enterococcus faecalis, Iron, Iron homeostasis

甄雨琦林泓兵徐智博姜鑫淼孟秀萍白玛曲珍. 粪肠球菌铁稳态维持对其生存和致病性影响的研究进展[J]. 口腔生物医学, 2024, 15(4): 240-244.

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