牙龈卟啉单胞菌感染影响宿主DNA损伤修复机制的研究进展

摘要/Abstract

摘要： 牙龈卟啉单胞菌（P. gingivalis）是牙周感染的关键致病菌，具有激活炎症反应、内化宿主细胞逃避免疫清除、重塑宿主细胞生物学行为等多种致病机制。随着对微生物感染研究的深入，越来越多的证据提示微生物感染与宿主细胞DNA损伤密切相关。本文从P. gingivalis的主要致病性出发，探讨P. gingivalis影响宿主细胞DNA损伤和修复能力的研究进展，为探索P. gingivalis的深层致病机制提供新的思路。

Abstract: Porphyromonas gingivalis （P. gingivalis） is a key pathogen in periodontal infections, with various pathogenic mechanisms such as activation of inflammatory responses, internalization of host cells to evade immune clearance, and reshaping of host cell biological behaviors. As research into microbial infections progresses, increasing evidence suggests that microbial infection is closely related to DNA damage of the host cell genome. This article aims to discuss research progress on how P. gingivalis affects DNA damage and repair capabilities of host cells from the perspective of its main pathogenicity, providing new insights for exploring the deeper pathogenic mechanisms of P. gingivalis.

中图分类号:

R781.4+2

马一欣鲁泽潘亚萍. 牙龈卟啉单胞菌感染影响宿主DNA损伤修复机制的研究进展[J]. 口腔生物医学, 2025, 16(2): 101-106.

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