›› 2013, Vol. 4 ›› Issue (1): 11-14.

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Expression of genes of the oligodendrocyte lineage-myelin basic protein in oral lichen planus

  

  • Received:2013-01-08 Revised:2013-02-28 Online:2013-03-25 Published:2013-03-30

Abstract: Abstract: Objective To study the expression of Golli-MBP (genes of the oligodendrocyte lineage-myelin basic protein,Golli-MBP) in lesions of oral lichen planus (OLP). Methods The mRNA expression level of Golli-MBP in 39 OLP tissues and 16 normal oral mucosa tissues was detected by real-time fluorescence quantitative PCR. The expression of Golli-MBP was also investigated in OLP (38 cases) and normal oral mucosa specimens (20 cases) using immunohistochemical technique. Results Increased Golli-MBP mRNA expression was found in OLP than that in normal oral mucosa(P<0.001). Expression of Golli-MBP in paraffin-embedded biopsy specimens was significantly higher in OLP than in normal controls(P<0.001); Golli-MBP expressed significantly higher in lymphocytes of OLP than in normal controls (P<0.05), while there were no significant differences in epithelial cells(P>0.05). Conclusions The data accumulated here indicate that the overexpression of Golli-MBP in OLP may play a role in the pathogenesis of OLP.

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