初级纤毛调控软骨发育和力学感知的研究进展

Abstract

Abstract: Primary cilia are present on the surface of most mammalian cells as signal sensors, and their structural and functional defects lead to a series of human multi-system syndrome called Ciliopathies. Some patients with Ciliopathies display dyschondroplasia, which seriously affects the development of skeletal system including craniofacial bones, suggesting the important role of primary cilia in chondrogenesis and homeostasis. Meanwhile, the structure and function of primary cilium are closely related to the mechanosensation of chondrocytes. In this review, we discuss the role of primary cilia in the regulation of chondrocyte fate and mechanical transduction, and further understanding of the research progress in is expected to promote the development of the treatment of cartilage related diseases.

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Research progress of primary cilia in regulating cartilage development and mechanosensation

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