Abstract: Titanium and titanium alloys are the most widely used materials for artificial implants, but there are risks of early insufficient osseointegration and infection around the implants, and modify the surface of the implants with drug or bioactive factor can effectively improve the antibacterial properties or promote osseointegration. At the same time, to prevent the initially explosive release of the loaded drug in the coating and the poor long-term effect, the application of sustained-release drugor bioactive fact or loading system on the surface of implants is increasing. This article summarizes the methods of sustained-release systems that have been applied on implant surface in this field in recent years.