Abstract: D-Mannose is a kind of monosaccharide that widely distribute in body fluids and tissues, especially in nerves, skin, testis, retina, liver and intestines. It could display multiple functions. D-Mannose can inhibit the colonization of pathogenic microorganisms and prevent urinary tract infection. D-Mannose could also play an anti-tumor function by inhibiting glucose metabolism of tumor cells. In addition, D-Mannose can regulate the immune response by regulating host immune cells and intestinal flora. In recent years, the biological effects of D-Mannose have been more and more deeply understood by scholars. This paper reviewed the latest progress of medical research on mannose and pointed out the potential of mannose in clinical application.

Key words: D-Mannose, Neoplasms