Oral Biomedicine ›› 2022, Vol. 13 ›› Issue (3): 185-190.

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Research progress on key mechanisms of tooth morphogenesis regulation

  

  • Received:2022-04-25 Revised:2022-07-21 Online:2022-09-25 Published:2022-09-29

Abstract: Tooth development is an organogenetic process in which epithelial-mesenchymal interactions and differentiation are precisely regulated by a complex cascade network of signaling molecules. In this paper, from the perspective of the changes in the fate of dental germ epithelial and mesenchymal cells in different stages of tooth morphogenesis, the research progress of morphological regulation during tooth development in recent years is reviewed, in order to improve the understanding of organ development and morphogenesis, and provide ideas and references for precise regulation of the regenerated tooth morphology during tooth regeneration.

Key words: tooth development, morphogenesis, epithelial-mesenchymal interaction, signaling molecules