Oral Biomedicine ›› 2022, Vol. 13 ›› Issue (3): 195-202.

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Research Progress on the effect of Bmal1 Gene on the growth and Development of Dental hard tissue

  

  • Received:2022-04-15 Revised:2022-08-01 Online:2022-09-25 Published:2022-09-29

Abstract: Bmal1 is the core gene of biological clock genes, which dominates the expression and translation of other biological clock genes through negative feedback regulation. The development of dental hard tissue is a series of complex physiological processes, including the formation and mineralization of enamel, dentin and cementum matrix. Bmal1 gene, as the core gene of biological rhythm, has an important effect on the development of dental hard tissue. This paper reviews the research progress of the effect of Bmal1 gene on the growth and development of dental hard tissue.

Key words: Bmal1 gene, circadian rhythm, enamel, dentin, cementum