Abstract: Diabetes and periodontitis were chronic inflammatory diseases caused by a variety of complex factors. They were closely related with each other. Both diabetes and periodontitis were urgent health problems that our society is currently grappling with. The high glucose microenvironment will significantly increase the incidence of periodontal disease and accelerate bone loss, hinder periodontal regeneration and bring great challenges to periodontal treatment. Starting from the pathogenesis of periodontal disease, this review introduced the effects of high glucose microenvironment on periodontal tissue cells such as epithelial cells, immune cells and stem cells, and proposed corresponding targeted therapeutic strategies for future periodontal treatment under high glucose microenvironment.

Key words: high sugar microenvironment, periodontitis, immune cells, stem cell, epithelial cell