Abstract: The repair of defects in the craniomaxillofacial region presents significant challenges in clinical practice. Various biomaterials for craniomaxillofacial tissue engineering are emerging as potential alternatives to autologous tissue transplantation. By integrating the developmental physiology of craniomaxillofacial tissues with the regenerative mechanisms of injury repair, this article reviews key advancements in the field of bionic regenerative repair of craniomaxillofacial tissue defects, drawing on our research findings. Furthermore, it explores the critical role of bionics in tissue engineering, aiming to provide fresh insights and innovative ideas for the design of future tissue engineering tools and strategies.

Key words: Regeneration of craniomaxillofacial tissues, biomaterials, biomimetic restoration