SNRNP200基因的研究进展

›› 2020, Vol. 11 ›› Issue (4): 262-264.

SNRNP200基因的研究进展

苏晓敏¹,范志朋²

1. 首都医科大学附属北京口腔医院
2. 首都医科大学附属北京口腔医院研究所

收稿日期:2020-07-27 修回日期:2020-10-27 出版日期:2020-12-25 发布日期:2020-12-31
通讯作者: 范志朋 E-mail:zpfan@ccmu.edu.com
基金资助:
国家自然科学基金

Research progress of gene SNRNP200

Xiaomin -Su¹,

Received:2020-07-27 Revised:2020-10-27 Online:2020-12-25 Published:2020-12-31

摘要/Abstract

摘要： SNRP200为核前体mRNA的剪接基因，编码的蛋白质属于RNA解旋酶的DExH-box蛋白家族，其在全身组织中广泛表达。SNRNP200与前体mRNA的剪接密切相关，可以通过影响剪接来调控有关基因的表达，从而影响细胞的增殖。此外，SNRNP200在遗传性视网膜色素变性及急性髓系白血病发病中也起着重要作用。本文对SNRP200的结构特征、功能调控及对疾病的影响等方面作一系统综述。

关键词: SNRNP200, 前体mRNA, 剪接

Abstract: SNRP200 is the splicing gene of nuclear precursor mRNA, and the encoded protein belongs to DEXH-box protein family of RNA helicase, which is widely expressed in the whole body tissues. In recent years, studies have shown that SNRNP200 is closely related to the splicing of precursor mRNA, and it can regulate the expression of related genes by influencing splicing, thus affecting cell proliferation. In addition, SNRNP200 also plays an important role in the pathogenesis of hereditary retinitis pigmentosa and acute myeloid leukemia (AML). In this paper, the structural characteristics, functional regulation and effects on diseases of SNRNP200 were reviewed.

Key words: SNRNP200, Pre-mRNA , Splice

苏晓敏范志朋. SNRNP200基因的研究进展[J]. 口腔生物医学, 2020, 11(4): 262-264.

Xiaomin -Su. Research progress of gene SNRNP200[J]. Oral Biomedicine, 2020, 11(4): 262-264.

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