初级纤毛调控软骨发育和力学感知的研究进展

摘要/Abstract

摘要： 初级纤毛作为信号传感器存在于大多数哺乳动物细胞表面，其结构和功能缺陷会导致一系列被称为纤毛病的人类多系统综合征。部分纤毛病患者表现出明显软骨发育不良，严重影响包括颅颌面部在内的骨骼系统发育，初级纤毛在软骨发育和稳态维持中具有重要作用。同时，初级纤毛的结构和功能与软骨细胞的机械感知密切相关。本文就初级纤毛在调控软骨细胞命运及机械转导中的作用进行综述。

Abstract: Primary cilia are present on the surface of most mammalian cells as signal sensors, and their structural and functional defects lead to a series of human multi-system syndrome called Ciliopathies. Some patients with Ciliopathies display dyschondroplasia, which seriously affects the development of skeletal system including craniofacial bones, suggesting the important role of primary cilia in chondrogenesis and homeostasis. Meanwhile, the structure and function of primary cilium are closely related to the mechanosensation of chondrocytes. In this review, we discuss the role of primary cilia in the regulation of chondrocyte fate and mechanical transduction, and further understanding of the research progress in is expected to promote the development of the treatment of cartilage related diseases.

陶狄坷张蕾耿江予孙瑶. 初级纤毛调控软骨发育和力学感知的研究进展[J]. 口腔生物医学, 2022, 13(1): 58-62.

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