牙周微生物与阿尔茨海默病相关性的研究进展

口腔生物医学 ›› 2022, Vol. 13 ›› Issue (3): 180-185.

牙周微生物与阿尔茨海默病相关性的研究进展

周亦凝¹,宋忠臣²

1. 上海交通大学附属第九人民医院口腔医学院
2. 上海交通大学医学院附属第九人民医院·口腔医学院牙周病科；国家口腔疾病临床医学研究中心；上海市口腔医学重点实验室；上海市口腔医学研究所

收稿日期:2022-05-13 修回日期:2022-07-22 出版日期:2022-09-25 发布日期:2022-09-29
通讯作者: 宋忠臣 E-mail:szhongchen@sina.com
基金资助:
基于STAT3调控的Th17/Treg免疫失衡在牙周炎所致认知损害中的作用探究;基于结构特征的牙龈素抑制剂高通量筛选在牙周炎所致认知障碍中的化学生物研究

Research progress on the relationship between periodontal microorganisms and Alzheimer’s disease

¹,

Received:2022-05-13 Revised:2022-07-22 Online:2022-09-25 Published:2022-09-29

摘要/Abstract

摘要： 阿尔茨海默病（AD）是老年人群常见的神经退行性疾病，但其病因和发病机制复杂。越来越多的证据表明牙周微生物及其与宿主之间的相互作用和炎症反应可能与AD的发病和进展密切相关。本文就牙周微生物与AD相关性及其可能机制，以及靶向牙周微生物对于AD治疗的意义进行综述。

关键词: 阿尔茨海默病, 牙周微生物, 菌群失调, 神经炎症

Abstract: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly population. However, the etiology and pathogenesis of AD are complicated and remain elucidated. Increasing reports suggest that periodontal microorganisms may play a role in the initiation and progress of AD. Thus, this article will review the association and potential mechanisms between periodontal microorganisms and AD, and explain the significance of management targeting periodontal microorganisms in the treatment of AD.

Key words: Alzheimer’s disease, Periodontal microorganisms, Microbial dysbiosis, Neuroinflammation

周亦凝宋忠臣. 牙周微生物与阿尔茨海默病相关性的研究进展[J]. 口腔生物医学, 2022, 13(3): 180-185.

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