施万细胞来源的外泌体在骨代谢中的作用

口腔生物医学 ›› 2023, Vol. 14 ›› Issue (1): 50-53.

施万细胞来源的外泌体在骨代谢中的作用

朱嘉言¹,李奇林¹,徐子航¹,胥春^1,2*

１．上海交通大学口腔医学院，国家口腔医学中心，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，

２．上海交通大学医学院附属第九人民医院口腔修复科，

收稿日期:2022-09-29 修回日期:2023-02-19 出版日期:2023-03-25 发布日期:2023-03-29
通讯作者: 胥春 E-mail:imxuchun@163.com
基金资助:
国家自然科学基金

Effect of exosomes from shwann cells under bone metabolism

Received:2022-09-29 Revised:2023-02-19 Online:2023-03-25 Published:2023-03-29
Supported by:
The National Natural Science Foundation of China

摘要/Abstract

摘要： 施万细胞（SCs）是一种重要的周围神经细胞，研究显示SCs等周围神经组织细胞在骨组织代谢中具有重要的调节作用。SCs可能通过其分泌的外泌体影响Wnt、MAPK、Hippo等信号通路，促进骨髓间充质干细胞等的成骨分化，参与体内骨代谢稳态的调节过程。关注SCs来源的外泌体在成骨分化中的作用及其机制，或将为今后研究骨再生机制、促进骨再生以及探索颌骨缺损修复新的治疗手段提供参考数据和研究方向。

Abstract: Schwann cells (SCs) are an important type of peripheral nerve cell and studies have shown that peripheral nerve tissue cells such as SCs have an important regulatory role in bone tissue metabolism.By affecting Wnt, MAPK, Hippo and other signaling pathways, exosomes of Schwann cell origin may promote osteogenic differentiation of bone marrow stromal stem cells and others, and participate in the regulation of bone metabolic homeostasis in vivo. Focusing on the role of exosomes of Schwann cell origin in osteogenic differentiation and its mechanism may provide reference data and research directions for future studies on bone regeneration mechanisms, promotion of bone regeneration and exploration of new therapeutic means for jaw bone defect repair.

朱嘉言李奇林徐子航胥春. 施万细胞来源的外泌体在骨代谢中的作用[J]. 口腔生物医学, 2023, 14(1): 50-53.

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