›› 2019, Vol. 10 ›› Issue (3): 123-126.

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Study of the effect of soluble epoxide hydrolase inhibitor TPPU in the treatment of peripheral neuralgia

  

  • Received:2019-03-28 Revised:2019-09-09 Online:2019-09-25 Published:2019-09-25
  • Supported by:
    81771032

Abstract: Objective:To study the effects of soluble epoxide hydrolase inhibitor 1-(trifluoromethoxyphenyl)-3-(1-propionylpieridn--yl) urea (TPPU) on peripheral neuralgia by targeted blockade of soluble epoxide hydrolase.Methods:The chronic neuropathic pain were generated by chronic constriction injury of the sciatic nerve in SD rats. The rats were administrated with TPPU (experimental group) or without TPPU (control group) by gastric lavage daily 3 days before surgery to 7 days after surgery. The body weight and pain threshold (Von Frey assay)were measured. Immunohistochemical staining was used to observe the number of nerve neovascularization and the expression of Nissl bodies in the sacral part of the spinal cord.Results:Pain threshold and body weight gain in the experimental group were significantly higher than those in the control group (P<0.05). Immunofluorescence results showed that the local microcirculation was improved in the TPPU-treated group, and the expression of Nissl bodies was higher than that in the control group (P<0.05).Conclusions:TPPU targeted blockade of soluble epoxide hydrolasemay promote nerve damage repair and reduce nerve injury pain by improving the microcirculation

Key words: Epoxytetracosic acid , Soluble epoxide hydrolase inhibitor , 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, Sciatica, Microcirculation